"I think that Tottenham are a side with characteristics and a way of playing which have bedded in and they will play the game they are capable of playing, which is an open, attacking, physically and technically strong football which will certainly cause us problems", he said.
On the other side of the coin, Tottenham will hope to pull off a major upset.
It's an extremely tough game to predict, because of the outcome of the first leg. After battling back from 2-0 down in Italy, Spurs will start as slight favourites at Wembley in a match that kicks off at 7.45pm.
Meanwhile, Pochettino's master plan of gradually and systematically making headway towards their goal of becoming a European powerhouse, won't have Harry Kane leaping out of his chair.
Tottenham are unbeaten in their last four games since their Champions League exploits in Turin and have booked their place in the FA Cup quarter-finals.
Tottenham Hotspur's (left) Roman Pavlyuchenko, Michael Dawson (centre) and Gareth Bale celebrate winning their Champions League last-16 tie with AC Milan in 2011 after the final whistle at White Hart Lane (pic: Sean Dempsey/PA Images). It's obvious there is a certain amount of pessimism after the first leg.
Tottenham proceeded to win their next two games in the competition, beating Borussia Dortmund and APOEL to top Group H with a remarkable 16 points from a possible 18.
"The players would be heroes because they will have competed with these big sides". They will look to take a similar approach at Wembley of staying tight at the back and nicking a goal.
The first leg ended 2-2 in Turin as Spurs rallied from a awful start, but they can't afford to be complacent in the second leg. The Argentine has made 21 appearances this season, but most of those have been as a substitute, a role in which he is likely to find himself on Wednesday night.
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